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Latest research

1. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations

   Annamarie E Bustion, Renuka R Nayak ... Katherine S Pollard

   Computational reaction representations and profile hidden Markov model searches of metagenomics databases can be harnessed to accurately predict bacterial species and enzyme sequences responsible for biotransformations in the human gut microbiome.
2. 1. Cell Biology

   An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo

   Peter H Lee, Michael Anaya ... Kai Zinn

   The cell-surface protein Stranded at second is a targeting ligand for extracellular vesicles that can deliver dArc1 capsids containing dArc1 mRNA to distant cells in vivo.
3. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

   Wenxin Zhang, Taki Nishimura ... Sharon A Tooze

   cis-membrane insertion of human ATG8 N-terminus facilitates autophagosome membrane expansion independent of autophagic cargo.
4. 1. Evolutionary Biology
   2. Genetics and Genomics

   Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

   David A Murphy, Eyal Elyashiv ... Guy Sella

   Background selection is shown to be the dominant mode of linked selection in humans, with marked effects on diversity levels throughout autosomes.
5. 1. Neuroscience

   Rats emit aversive 44-kHz ultrasonic vocalizations during prolonged Pavlovian fear conditioning

   Krzysztof H. Olszyński, Rafał Polowy ... Robert K. Filipkowski
6. 1. Neuroscience

   MotorNet: a Python toolbox for controlling differentiable biomechanical effectors with artificial neural networks

   Olivier Codol, Jonathan A. Michaels ... Paul L. Gribble
7. 1. Developmental Biology

   A MSTN^Del273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia via MEK-ERK-FOSL1 axis

   Ming-Ming Chen, Yue Zhao ... Zheng-Xing Lian
8. 1. Computational and Systems Biology

   Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells

   Silvia Liu, Yan-Ping Yu ... Jian-Hua Luo
9. 1. Medicine

   An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo

   Luyang Cao, Lixiang Ma ... Jingsong Xu
10. 1. Neuroscience

    Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making

    Mariann Oemisch, Hyojung Seo